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KMID : 0616120120430010066
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Korean Journal of Pharmacognosy
2012 Volume.43 No. 1 p.66 ~ p.71
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Protective Effects of Leaf and Flower Extracts from Cirsium japonicum var. ussuriense on Oxidative Damage in Normal Human Erythrocytes and Plasma
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Kang Hyun-Ju
Mok Ji-Ye
Cho Jung-Keun
Jeon In-Hwa
Kim Hyeon-Soo
Park Ji-Min
Jeong Seung-Il
Shim Jae-Suk
Jang Seon-Il
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Abstract
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Cirsium japonicum var. ussuriense is often used in treatment of human disease such as hemorrhage, blood congestion and inflammation. This study was accomplished to evaluate the antioxidant properties of the leaf (CLE) and flower (CFE) extracts of C. japonicum var. ussuriense to protect normal human red blood cells (RBC) and plasma samples against oxidative damage in vitro. CLE and CFE were prepared by extracting with hot water. In red blood cells and plasma, oxidative hemolysis and lipid peroxidation induced by the aqueous peroxyl radical generator [2,2’-azobis (2-amidinopropane) dihydrochloride, AAPH] were significantly suppressed by CLE or CFE in a dose-dependent manner at the same time. CLE and CFE also prevented the depletion of cytosolic antioxidant glutathione (GSH) in RBC. These results suggest that the leaves and flowers of C. japonicum var. ussuriense may have the antioxidant properties.
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KEYWORD
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Cirsium japonicum var. ussuriense, Oxidative damage, Antioxidant
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